Duke Nukem: Manhattan Project is an action-packed video game set in New York City. Players take control of Duke as he battles against the power-hungry villain, Mech Morphix, across towering skyscrapers and gritty subway stations. Along his journey, Duke will face over 25 uniquely dangerous mutated enemies such as Uzi-sporting alligators and ten-foot tall roach beasts. He must also avoid the green slime called GLOPP that is causing chaos around him while attempting to save babes in distress. To help him fight off these foes, Duke has access to weapons like a machine gun, pipe bombs, a rocket launcher and pulse cannon - making for a goo-filled mess in The Big Apple!

Duke Nukem Forever is an upcoming video game with no definite release date. 3D Realms has made it clear that any information pertaining to the game's launch or development timeline beyond "When it's done" is speculation and should be treated as such. They have also noted that if anyone claims to know a specific launch date, they are making it up. Moreover, the long development time of Duke Nukem Forever has been acknowledged by 3D Realms, noting that there are few jokes related to this left unheard at this point.