In 50 Cent: Bulletproof, the player takes on the role of 50 Cent as he navigates through the criminal underworld of New York. Along with his G-Unit crew, players will face off against some of the largest crime families in New York while also performing various acrobatic moves to chase down and take out enemies. The story was written by Terry Winter, executive producer of The Sopranos, and features additional content from 50 Cent himself in the form of music tracks, freestyles and dialogue.

50 Cent: Blood on the Sand is a third-person action/shooter video game. After performing a sold out concert in a fictional war-torn country, 50 Cent and his G-Unit are robbed of their money and paid with an incredibly valuable diamond encrusted skull. Determined to seek revenge, 50 Cent sets off to reclaim what is owed to him. The game features intense action gameplay, an intuitive cover system, drop in and drop out online multiplayer co-op mode, merciless melee counter kills and a soundtrack that combines 50 Cent's greatest hits with 18 exclusive new tracks. Visuals from the Unreal 3 engine technology combine with an over-the top story featuring voiceover work by 50 Cent and other members of the G Unit for an immersive virtual experience.