Papo & Yo is an emotional journey that follows the relationship between a boy and his best friend Monster. Players must learn to use Monster's emotions to their advantage, both good and bad, as they progress in order to complete their search for a cure and save him. Depending on what Monster needs or desires at any given time, he will react differently; if he wants food he may seek it out but if it happens to be poisonous frog then he turns into a destructive killing machine. By learning how best to manage his emotions players are able to help Quico in his quest for a cure.